(23) New Derivatives of Fluoroacetic Acid.

Quantitation of Fluoroacetic Acid and Fluoroacetamide with Mass Spectrometric Detection

Fluoroacetate (Compound 1080) and fluoroacetamide are strong metabolic poisons commonly used as rodenticides and predacides.1,2 Fluoroacetic acid is also an intermediate metabolite of many compounds, such as anticancer drugs 5-fluorouracil and fluoroethyl nitrosourea. Fluoroacetate is cheap and simple to synthesize, tasteless, and has a high solubility in water. Due to their high level of toxic...

The effect of pH on the toxicity of fluoroacetic acid.

New Artificial Intelligence Modeling for the Photocatalytic Removal of C.I. Acid Yellow 23 in ‎Wastwater

This paper proposes two methods to predict the efficiency of photochemical removal of AY23 by UV/Ag-TiO$_{2}$ process. In this work the potential of the particle swarm optimization (PSO) and imperialist competitive algorithm (ICA) modeling approaches are presented to forecast the photocatalytic removal of AY23 in the presence of Ag-TiO$_{2}$ nanoparticles prepared under desired conditions. To v...

Synthesis and biological activity of 23-hydroxybetulinic acid C-28 ester derivatives as antitumor agent candidates.

23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50 values of 8.35 µM in HL-60 cells and showed similar antitumor activity...

EFFECT OF FLUOROACETIC ACID AND ALLIED FLUOROANALOGUES ON GROWTH OF ESCHERICHIA COLI I. PATTERN OF INuHIBITION

The pharmacological and biochemical aspects of fluoroacetate poisoning have been intensively studied in different animal species (Chenoweth, 1950). The work of Martius (1949) and the fundamental researches of Peters and his asociates (1952a, 1952b) demonstrated that fluoroacetic acid is transformed in vivo into fluorocitric acid. The latter blocks the Krebs cycle at the citric acid stage by int...